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SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of beta-thalassaemia

Ferroptosis attenuation decreased -syn-induced cell death in vitro and protected against -syn-related toxicity in vivo, suggesting that the ferroptosis pathway contributes to PD pathology, and improving their targeting approaches might alleviate PD pathology and symptoms