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STING is transported by clathrin-coated vesicles and recycling endosomes (141) and directly encapsulated in lysosomal associated membrane protein 1 (LAMP-1) positive compartments through the ESCRT components tumor susceptibility gene 101 (TSG101) and vacuolar sorting-associated protein 4 (VPS4) (165)

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Anabolic Signaling in Preclinical Models In preclinical models, activation of this pathway is associated with several downstream signaling events: increased protein synthesis via mTOR activation, stimulation of satellite cells that contribute to muscle fiber development, and inhibition of the FOXO pathway, which under normal conditions promotes protein breakdown