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Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells

The vast majority of evidence comes from MCT or hypoxia animal models, whose pathological characteristics differ from human PH, lacking in-depth verification in models that are more similar to human disease states

Based on these studies and studies involving GSH depletion, it was concluded that a reduction in GSH levels and GPX activity before infection could decrease spread of the virus due to apoptosis caused by oxidative microenvironment (48,49)

In addition, GPX4 is highly expressed in most of acute myeloid leukemia (AML) subtypes compared to normal hematopoietic stem cells