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it reflects a growing recognition of the central role of metabolic dysfunction in the pathogenesis of steatotic liver disease and aligns diagnostic criteria with our expanding understanding of its underlying mechanisms

The independent acquisition of the CSD in two clades, primates and muroids, at roughly the same epoch ~75 MYA is interesting, and could arise from an environmental change, for example in the oxygenation of the Earth's atmosphere

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895 In D-galactose-induced aging mice, the vitamin D receptor activator 1,25-(OH) 2 -D 3 alleviates D-galactose-induced osteoblast ferroptosis, manifested by improved mitochondrial morphology and decreased lipid peroxidation markers, and the mechanism may be related to the activation of the Nrf2/GPX4 signaling pathway to reduce osteoblast ferroptosis