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Unfortunately, GBM remains largely resistant to treatment and is associated with a poor prognosis, with an average survival of 15 months after diagnosis and less than 10% of patients surviving 5 years post-diagnosis (Ostrom et al., 2015)

Furthermore, blocking BDNF abolished the antidepressant-like effects of fucoidan in mice, indicating that fucoidan ameliorates depression by inhibiting inflammation and modulating synaptic plasticity (Li et al., 2020)

Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13

As awareness of acute intermittent porphyria increases among healthcare professionals and patients, clinics are becoming more involved in the early detection and diagnosis of the disorder