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doi: 10.1016/j.bbrc.2005.08.020 45 KrzeptowskiW.ChudyP.SokoowskiG.ukowskaM.KusienickaA.SeretnyA.et al

A quintessential methylation status of MSCs is that the expression of stemness-associated genes should be hypomethylated

Mol Med 2024

Pathological immobilisation of iron by protein aggregates such as amyloid and tau may sequester iron in a non-bioavailable form, or impaired autophagy may prevent efficient breakdown of ferritin to mobilise iron, thereby impairing mitochondrial ATP production and subsequently glutathione synthesis, an essential component of the ferroptosis defence system [29]