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We compared our candidate drugs to known anti-melanoma and NO-based drugs using publicly available drugs screens and high-throughput CRISPR data and experimentally validated six of these candidates in BRAF and NRAS mutated cell lines in mono and combination treatment with BRAF/MEK inhibitors

These NPs, with sizes ranging from 200 to 300 nm and a surface charge of 20 to 30 mV, demonstrated increased retention time on ocular tissues due to their mucoadhesive properties

Acetyl-L-carnitine Carnitine is an essential nutrient that is important for fatty acid transfer across the inner mitochondrial membrane, especially in hepatocytes

Brazilian J Med Biol Res 37(4):451458