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In this model, the de novo lipogenesis in the cells was enhanced and the cells showed symptoms of oxidative stress, inflammation, fibrosis and activation of hepatic stellate cells (207)

Chapter FiveGlutathione: A powerful but rare cofactor among Actinobacteria

These KPFs include genetic predisposition and injury triggered by viral infections/toxins and/or niche abnormalities, with inflammatory and immune dysfunction, leading to obliteration and eventual fibrosis and atresia of the bile ducts (26)