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Based on the z scores of 19 selected canonical psoriasis-associated pathways, K14/Gpx4 showed the strongest correlation to human psoriasis datasets ( r = 0.750.96), as well as to K5-Stat3C ( r = 0.94) and idIL-23 ( r = 0.89) models, and weaker correlation to K14-AREG ( r = 0.62) and IMQ ( r = 0.170.56) models (Figure 5F, Supplemental Figure 9, A and B, and Supplemental Table 9)

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497 Astrocytes, however, also express GDI and vesicle traffic in astrocytes is similarly impaired in the absence of GDI1