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The mitochondria-targeting antioxidant MitoQ alleviated lipopolysaccharide/d-galactosamine-induced acute liver injury in mice

MoaddelRShardellMKhadeerMLovettJKadriuBRavichandranSet al

In acid sphingomyelinase knock-out mice, which mimic a neurovisceral acid sphingomyelinase deficiency (ASMD) characterized by cellular accumulation of sphingomyelin, the effects of a choline-free diet decreased the activation of liver macrophages and microglia, but it did not significantly alter sphingomyelin levels due to compensatory mechanisms involving methionine metabolism ( 2.2 Lymphocytes The phospholipid remodeling and cholinergic anti-inflammatory system play a well-established role in immune homeostasis and the regulation of inflammatory and autoimmune diseases