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(1) Iron compartmentalization strategies contrast systemic chelators like DFO/DFX, which fail to cross the BBB, with membrane-permeable agents like DFP/TPP-chelators that specifically access mitochondrial iron deposits

Historically, tumor-associated macrophages were defined as immune cells capable of phagocytosing cancer cells, resulting in lethal consequences, and were initially categorized as anti-tumorigenic entities (27)

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Cells treated with test compounds were washed with PBS and incubated with 10 M 2,7-dichlorofluorescein diacetate (DCFH-DA) at 37 C for 30 min, followed by washing with PBS, digestion with trypsin, and collection