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Individuals with certain chronic diseases, pregnant or breastfeeding women, and those allergic to specific peptides should consult their primary care physician before starting their treatment

This may identify the so-called parallel or non-parallel healing actions, with the final end result, positive (fistula closing) or negative (fistula remains open) (Skorjanec et al., 2009)

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For TJA, priority endpoints include wound complications, prolonged drainage, hematoma requiring intervention, early readmission, and PJI, with follow-up sufficient to capture early revision risk