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*Correspondence: Jianhua Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In the event that this system is used regularly with the 256X chip, the flow system could be adjusted to accommodate the 200 PSI that would theoretically be necessary to operate at a total flow rate of 31 L/hr

If nausea persists beyond 3-4 weeks on a stable dose, consider reducing to the previous dose level and attempting re-escalation more gradually after 4-6 weeks

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