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Nature 469 , 221225 (2011)

Indeed, Grx1 and GSH receiving electrons from NADPH via glutathione reductase, could serve as alternative reducing agents of the disulphide in Trx1 active site (Cys32 and Cys35)

In this review, we discuss the evolution in computational pharmacology as the next generation of successful drug discovery and implementation in the clinic where high-performance computing (HPC) is used to generate and validate drug-target-effect hypotheses completely in silico