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Both are investigational compounds studied only inside monitored clinical trials, and any material sold under either name outside those trials is a research-use-only chemical of unverified identity, with no established or approved human dose

Semax is a synthetic nootropic peptide derived from an ACTH fragment, designed to support cognitive function, memory, and neuroprotection

PE-22-28 offers a cleaner evidence base and a well-characterized pharmacological target, but its cognitive effects remain inferential rather than directly demonstrated

This is by design: the long half-life allows once-weekly dosing, but the trade-off is that side effects don't reset between doses