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Description

MK-677 (half-life 24 hours) requires a longer taper 3-4 weeks minimum because its prolonged receptor occupancy causes deeper suppression that takes 28-35 days to fully resolve

Funding This work was supported by grants from General Program of National Natural Science Foundation of China (82571371), National Key Research and Development Program of China (2021YFC2500102), and Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment (PTYX2025024)

Yee, Sook Wah, et al

Factors such as high pressure and speed, during sorting, dye-induced defects, electrical deviation, changes in pH and osmolarity, etc might lead to changes to the sperm plasma membrane, trigger pre capacitation-like changes, cause protamine decondensation and alter sperm DNA quality (68)