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13 Future directions Future advances in GSH-responsive nanomedicine should focus on clinically relevant development rather than proof of concept designs

GST-tagged Protein Purification Process The purification process for GST-tagged proteins is a well-established and highly efficient method that leverages the specific binding affinity between the GST tag and glutathione

Therefore, elucidating the molecular mechanisms underlying glial contributions to ALS pathogenesis is crucial for advancing our knowledge of the disease and the development of targeted therapeutic strategies

Stemming from real-world practical considerations wherein patients are followed up less frequently than in the trial setting, treatment interruption when aminotransferases increase to 3 ULN without other signs of hepatic impairment may be considered