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He was mysterious, otherworldly, but palpably evil perhaps depraved

Mathematical biologists have calculated that in theory, a vigorous running program should produce steady gains in longevity up to a point, after which the benefits of additional running time decline and eventually become negative

Given that many studies included in this meta-analysis did not report the time elapsed between last cigarette smoked and MRI data collection (Additional file 1: Table S2), this potential confounding factor cannot be ruled out