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Figure 6 Klotho Regulation and GH Secretion To date, it has not been clearly established how klotho secretion is regulated, although the fact that the kidneys are the main source of klotho suggests that hormones and factors involved in mineral homeostasis play a role in this regulation

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Signs of degradation Degraded GHK-CU may show visible changes: Cloudiness or particles in the solution Color changes (fresh solution should be clear to slightly yellowish) Unusual smell Clumping or precipitation When in doubt, discard