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Standard laboratory assays measure total serum B12, which includes vitamin bound to transport proteins

The HPA axis operates under the fundamental mechanism of negative feedback and assumes a pivotal function in eliciting the bodys stress response and governing various physiological processes, encompassing digestion, immune system functionality, and energy equilibrium (191)

This work was partially supported by the Research Council of Norway through its Centers of Excellence scheme, project number 332727, and its Proof-of-Concept Research commercialization program, project number 333902, as well as by the Novo Nordisk Foundation Pioneer Innovator Grant 0090894

The psychosocial effect of HS is devastating because of the associated pain, malodorous discharge, and scarring