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HGF influenced the metastasis of c-MET-positive cells into multiple organs, including the liver, kidney, lymph nodes, lung, gonads, and the central nervous system, in SCID mice but did not affect metastasis of c-MET-negative lymphoma [15]

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This cytokine signals in an autocrine/paracrine manner through the TNF receptor to activate the mitogen-activated protein kinases p44/42 and JNK that, in turn, downregulate perilipin mRNA and protein expression (104, 105)