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Furthermore, genetic deletion of Gpx1 markedly exacerbates atherosclerosis in Apoe -/- mice (398,399), while overexpression of Gpx4 in Apoe -/- mice inhibits atherogenesis (400)

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Use caution if you have kidney disease, thyroid disease, a seizure disorder, or if you take anticoagulants (such as warfarin) or thyroid hormone, since interactions may be possible