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Hou L, Huang R, Sun F, Zhang L, Wang Q (2019) NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis

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In healthy mitochondria, SIRT3 interacts with ATP5O, while the low pH owing to the loss of membrane potential weakens the binding affinity between SIRT3 and ATP5O, leading to the redistribution of SIRT3 to other mitochondria substrates