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Consistent with the observed downregulation of multiple inflammation-related pathways, immune cell deconvolution analysis using CIBERSORT revealed that LP-EVs treatment increased the relative abundance of M2 macrophages and Th17 cells while decreasing M1 macrophages (Figure S8), which suggests that the therapeutic potential of LP-EVs may stem from promoting an anti-inflammatory macrophage shift toward the M2 phenotype together with Th17-mediated tissue repair and barrier defense functions [69, 70]

215 (40.5%) of these infections were P