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In contrast, but with ultimately the same result, impairment of transsulfuration will lead to increased intracellular SAM concentrations and consequent inhibition of MTHFR, which reduces the formation of 5-methyltetrahydrofolate for remethylation and inhibits recycling of homocysteine through its conversion to methionine (16)

A more significant injury such as a Grade 3 sprain can take several months

In the largest trial conducted so far, a phase 2 study involving 706 overweight or obese participants, side effects were common across all dosage levels, ranging from 0.3 to 4.5 mg/week [11]

Common side effects include nausea, mucositis, liver toxicity, and bone marrow suppression, necessitating close monitoring during treatment