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In the meantime, the specific content of MMS formulations may evolve (for example, it is possible that higher levels of vitamin D could lead to more beneficial results)but this very much depends on current evidence and local guidelines and regulations

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In one prospective controlled trial, 100 patients at a single center in Italy who had experienced inadequate response to DMARD therapy were randomly assigned to open-label treatment with infliximab 5 mg/kg every 6 to 8 weeks, etanercept 25 mg twice-weekly or adalimumab 40 mg every other week