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Patients with PSC can develop varices even before cirrhosis develops

When iron stores cannot meet the increased demand, patients develop microcytic, hypochromic red cells, meaning that even though they have too many red blood cells, those cells are poorly hemoglobinized and less effective at oxygen delivery (Bessman, 1977

importante destacar que essa difuso no ocorreu a partir de consensos cientficos ou diretrizes clnicas, mas de extrapolaes de estudos experimentais iniciais