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2009 documented similar timelines in their photoaged-skin RCT 10

The longer-term picture is timing-dependent, since started near menopause it appears cognitively safe and may track with lower dementia risk, and the FDA removed the boxed warning, including the probable-dementia language, in 2026

It also seems to stabilize nitric oxide pathways, which are key to maintaining vascular health and controlling inflammation

Xu, C., Sun, L., Ren, F., Huang, P., Tian, Z., Cui, J., Zhang, W., Wang, S., Zhang, K., He, L., Zhang, W., Zhang, C., Hao, Q., Zhang, Y., Li, M., & Li, W