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Description

The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications

BPC-157 stands for Body Protective Compound 157. It is a synthetic peptide derived from a protein naturally found in gastric juice

The model predicts synergistic efficacy for combination of AXT050 with sorafenib, cabozantinib, and rilotumumab but not synergistic potency We next used the calibrated and validated model to investigate the effect of the combination of AXT050 with other therapeutics targeting HGF/Met signaling pathway to predict synergy