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Accordingly, SDH flux showed lower conversion into M2-fumarate in Gclc fl/fl Mb1-Cre + FoB compared to control cells (Supplementary Fig

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In contrast, inactivation of ABCC1 had no impact on cell proliferation in multiple AML cell lines in the absence of drugs, which is in line with previous data 68 , and ABCC1 inhibition did not sensitize AML cells to various other anticancer drugs that are used to treat AML, including the chemotherapeutic Cytarabine, FLT3-inibitors and IDH inhibitors