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The escalation phases are only required during the first cycle

9 Nrf2 is usually locked in the cytoplasm, but activation by DMF/MMF allows it to translocate to the nucleus where it activates a pathway of genes involved in antioxidant responses, detoxification, and the activity of cytoprotective anti-inflammatory factors

Pretreatment with Nicotinamide Mononucleotide increases the Effect of Ischaemic Postconditioning on Cardioprotection and mitochondrial function following Ex vivo myocardial reperfusion Injury in aged rats