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Proc Natl Acad Sci U S A 107:74197424

There are two primary types of melanin: Eumelanin: This is responsible for dark colors, such as black and brown

Subsequent network pharmacology analysis identified Genistein, Wogonin, and Kaempferol as the potential core active components

This response recruits neutrophils and mononuclear macrophages to the lungs, where they release superoxide anions, hydrogen peroxide and reactive oxygen species (ROS), thereby inducing oxidative stress in the airways (14)