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The snacks (mainly carbohydrate 47.3-61.8%) had low anti-nutrients with expansion ratios (2.8-3.1)

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OTUD5 counteracts UBR5-mediated K48 ubiquitylation, overcome by TRIP12 To investigate whether OTUD5 counteracted ubiquitin chain assembly, we conducted an in vitro ubiquitylation/deubiquitylation assay using wild-type or catalytically inactive (C224R) OTUD5 (OTUD5C224R)

These two major pathological hallmarks contribute to changes in numerous cellular and subcellular events, such as mitochondrial dysfunction, redox imbalance, and neuroinflammation that lead to activation of neurotoxic cascade towards cell death, thereby impairing synaptic communication [81,82]