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A.FreitasT.TuckerH.ShikeD

Periventricular leukomalacia Periventricular leukomalacia (PVL) is a diffuse damage of the cerebral white matter that extends beyond the periventricular regions found predominantly in preterm infants

Blood 105 , 47434748 (2005)

Consequently, the patient experiences a significant decrease in the international normalized ratio, placing them at increased risk for thrombotic complications such as mechanical valve thrombosis unless the warfarin dose is appropriately escalated