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This disrupts various signaling pathways, including those involved in tau phosphorylation, function of synapses, and survival of neuron cells

introduced a thioketal bond to connect camptothecin [60](CPT) with the photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide a (HPPH), forming a ROS-responsive prodrug (CPT-TK-HPPH)