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And they are terrifying

These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity

The study used isolated natural killer cells from long Covid patients and healthy controls to determine the effect of LDN on TRPM3 ion channels.[ref] Genetic variants in TRPM3 are associated with response to LDN