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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Running AOD-9604 in parallel with a GHRH analog or a pure 3-AR agonist helps clarify receptor-pathway contributions for any new mechanistic question

It's also important to understand that microneedling results are not permanent natural aging and collagen degradation continue over time, so maintenance treatments may be recommended