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A landmark 2019 clinical trial by Nordio et al

Melatonin mitigates oxidative stress, inflammation processes, and cell apoptosis by upregulating the Nrf2 signaling pathway and downregulating COX-2 protein levels (135), as well as SOD, GPx, CAT, and Bcl-2 activities (136)

Mapping phospho-catalytic dependencies of therapy-resistant tumors reveals actionable vulnerabilities

The most commonly reported side effects include: Pain, bruising, or redness at the injection site Mild nausea or stomach upset Diarrhea Headache Allergic reaction (rare) Because MIC injections are compounded formulations, the quality and composition can differ from one clinic to another