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For AOD-9604 specifically, COA documentation should confirm disulfide cross-link integrity, since the bridge is a defining structural feature affecting both stability and administration route

If the observed one-year event rate in this group of placebo participants is below 16%, the sample size will be increased by 40 participants to maintain at least 80% power for the study assuming a 66.7% event rate reduction in the NAC arm compared with placebo

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Nevertheless, in the present study, we detected that the patient group with Long COVID showed increased CRP levels compared with control levels, indicating a mild inflammatory response