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In other words, high levels of lactate in the GBM TME modulates RNA splicing only in the Treg cell (Foxp3-dependent, meaning it does not affect RNA splicing in other T-cells) to increase CTLA-4 expression on the Treg cell surface, thus enhancing its immunosuppressive effects and preventing effector T-cells from infiltrating and attacking the GBM tumor cells

Impaired Ca 2+ homeostasis can affect migration, proliferation, Purkinje cell development, dendritic arborization, synapse formation, and maintenance [94]

Hu W., Zhang C., Wu R., Sun Y., Levine A., and Feng Z., Glutaminase 2, a Novel p53 Target Gene Regulating Energy Metabolism and Antioxidant Function, Proceedings of the National Academy of Sciences of the United States of America 107, no

Park JW, Voss PG, Grabski S, Wang JL, Patterson RJ