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Similar content being viewed by others Introduction Deregulation of two major signalling pathways, the RAS-RAF-MEK-ERK and PI3K-AKT-PTEN, are key drivers of melanoma development and progression [1], with ~50% and ~25% of patients expressing constitutively active mutants of MAP-kinases BRAF and NRAS, respectively [2]

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A prospective approach to enhance the efficacy of CAR-T cell therapy involves the modulation of metabolic and differentiation status through the ex vivo inhibition of glutamine