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A P value of 0.05 for the Tukeys multiple comparison test, Dunnetts test, and Student t -test or AspinWelch t -test was considered to represent a statistically significant difference

IDH1 inhibitors AG-881 and BAY-1436032 induced a significant reduction in in vivo 2HG, a significant early and sustained increase in Glu, and a transient early increase in NAA concentration [114]