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Calzada Limited Annual Report (2008)

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Symptoms of vitamin B12 deficiency include (1): chronic fatigue shortness of breath heart palpitations tingling or numbness in the extremities poor balance loss of concentration poor memory disorientation mood changes incontinence insomnia People most at risk of developing a deficiency include older adults, as well as those who smoke, abuse alcohol, or follow a vegetarian or vegan diet

Figure 33 shows the time course of drug accumulation during a constant-rate drug infusion and the time course of drug elimination after stopping an infusion that has reached steady state