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mobile phase, 5 mM ammonium formate in acetonitrile/H 2 O (2:1, v/v) (A) and 5 mM ammonium acetate in isopropanol/H 2 O (95:5, v/v) (B)

Meta-analyses have shown that supplementation with NAD + precursors, including NMN, nicotinamide riboside (NR), NA, and NAM, significantly reduces levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL), while concurrently increasing high-density lipoprotein levels (Zhong et al., 2022)

In our systematic review, although a large number of preclinical studies and a small number of clinical studies have proved the efficacy and safety of Nrf2 activators in the treatment of ASD, caution should be warranted in attempting to extrapolate their effects in human studies

Overall, the selectivity of the SEL1L-HRD1 complex for selecting substrates defines important biological processes