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Abbreviations Akt: Protein kinase B Bcl-xl: B-cell lymphoma-extra large TGF-1: CD44: cluster of differentiation 44 CD44s: CD44 standard isoform CD44v: CD44 variant isoforms CSCs: Cancer stem cells CTCs: Circulating tumor cells DFS: Disease-free survival ECM: Extracellular matrix EMT: Epithelial-mesenchymal transition Erk: Extracellular signal-regulated kinase ERM: Ezrin/radixin/moesin ESCC: Esophageal squamous cell carcinoma FAK: Focal adhesion kinase GAB2: Growth factor receptor bound 2-associated binding protein 2 GSK-3: Glycogen synthase kinase-3 HA: Hyaluronic acid HNSCC: Head and neck squamous cell carcinoma IC50: Half maximal inhibitory concentration value ICD: Intracellular domain IL: Interleukin KHDRBS3: KH RNA binding domain containing, signal transduction associated 3 mAb: Monoclonal antibody MAPK: Mitogen-activated protein kinases MEK: Mitogen-activated protein kinase MMP9: Matrix metalloproteinase 9 NFB: Nuclear factor-kappa B NNMT: Nicotinamide N-methyltransferase NSAIDs: Nonsteroidal anti-inflammatory drugs OS: Overall survival OSCC: Oral squamous cell carcinoma PAK2: P21-activated kinase 2 PDK1: 3-Phosphoinositide-dependent kinase 1 PFKFB4: 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 PFS: Poor progression-free survival PI3K: Phosphoinositide 3-kinase RCC: Renal cell carcinoma