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Some tannins catabolites of the gut microbiota may have prebiotic activity, such as urolithin produced by pomegranate ellagitannins, which in preclinical studies has actively regulated lactic bacteria, Bifidobacteria and enterobacteria model of intestinal inflammation in rats (55)

2013), and ellagic acid from the fruit (Zhang et al

The Zn 2+ ion plays a structural role and is required for an efficient SOD1 folding and long-term stability 2 , whereas active-site Cu 2+ catalyzes O 2 dismutation by alternating between the reduced and oxidized states (Reactions 1 and 2): In the nervous tissue, SOD1 is present at exceedingly high concentrations (~1% of total protein, i.e., 100200 M) 3 and is traditionally regarded as cytosolic protein 4