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GSH is critical for growth upon nutrient deprivation and is secreted to support the proliferation of GSH-deficient cells Because GSH is also vital for synthesis of proteins and DNA, we sought to characterize the impact of GSH deficiency in gsh2 mutants on growth under nutrient-depletion, which mimics the nutrient-sequestered host environment

Ding R, Zhu S, Zhao X, et al

This approach has allowed us to identify novel DNA adducts, including cross-links in several experimental settings, including tobacco-specific nitrosamine NNK 71 , the gut bacterial-derived genotoxin colibactin 72 , and the chemotherapy agents busulfan and cyclophosphamide 73,74

Mesenchymal stem cells decrease blood-brain barrier permeability in rats with severe acute pancreatitis