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In RPE of AMD patients, the expression of circSPECC1 is downregulated, and circSPECC1 insufficiency leads to oxidative stress-induced ferroptosis, depolarization, and irregular lipid metabolism via circSPECC1/miR-145-5p/CDKN1A axis, and then induces visual impairments and RPE anomalies and interrupts retinal homeostasis (Chen X