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46 The data from these mice, similar to those subjected to a transient increase in gut permeability, suggest that under conditions of compromised gut permeability, there are adaptive immune components activated in response to the hyperactivated immune system, and that these immune compensatory mechanisms may help provide resistance to colitis

The current data is promising but largely preclinical

SLU-PP-332

The center should ensure DSD patient care throughout his (or her) life and ensure the effective transition of care from childhood through adolescence to adulthood [126, 127]