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PMID 23123585

In case of deficiency, you may show symptoms such as: Loss of appetite Depression and mood changes due to lack of appetite

doi: 10.3945/ajcn.116.141978

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default